For research use only. PT-141 is not approved by the FDA for human use as a research chemical and is sold by Iron Labs exclusively for laboratory research. Not for human consumption.
What Is PT-141?
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide melanocortin receptor agonist. It is a metabolite of Melanotan II, derived by removal of the C-terminal amide group. PT-141 acts primarily on melanocortin receptors MC3-R and MC4-R in the central nervous system. Unlike Melanotan II, PT-141 was developed with a more targeted receptor profile and has been studied specifically in the context of central nervous system signaling pathways related to arousal and vascular biology.
PT-141 in Preclinical Research
- Melanocortin receptor biology: PT-141 has been studied as a selective MC3-R and MC4-R agonist, with research examining downstream cAMP signaling and receptor internalization kinetics in cell culture models.
- Central nervous system signaling: Animal research has examined PT-141’s effects on hypothalamic signaling pathways and limbic system activity, with particular focus on its CNS-mediated mechanism compared to peripherally-acting compounds.
- Vascular biology: Some preclinical research examined PT-141 in models of vascular tone and blood pressure regulation, noting its effects on mean arterial pressure in animal models.
- Receptor selectivity studies: Compared to earlier melanocortin agonists, PT-141 research has highlighted its relative selectivity for MC3R and MC4R versus MC1R and MC5R, providing researchers a tool for receptor subtype differentiation studies.
PT-141 vs. Melanotan II: Research Profile Comparison
PT-141 and Melanotan II share a common structural origin but have distinct research profiles. Melanotan II binds broadly across melanocortin receptors including MC1R (relevant to pigmentation research) and has been studied extensively in tanning and appetite models. PT-141’s more selective CNS profile makes it a preferred tool when researchers wish to isolate MC3R/MC4R signaling without confounding MC1R activity.
Laboratory Handling
PT-141 is supplied as lyophilized powder. Reconstitute with bacteriostatic water. Store lyophilized stock at -20°C; reconstituted solution at 2–8°C for up to 28 days. Light-sensitive — store in opaque container. PT-141 is a cyclic peptide with good stability relative to linear analogues.
Source PT-141 for your research → Iron Labs Research Catalog
Regulatory Notice
PT-141 sold by Iron Labs is a research chemical for laboratory use only. It is not FDA-approved for human use in this context. Iron Labs makes no health or therapeutic claims regarding PT-141.