For research use only. TB-500 is not approved by the FDA for human use and is sold exclusively as a research chemical. Not for human consumption.
What Is TB-500?
TB-500 is a synthetic peptide derived from the C-terminal region of Thymosin Beta-4 (TB4), a naturally occurring protein found in virtually all human and animal cells. The active fragment studied in most research contexts is the amino acid sequence LKKTETQ. TB-500 has drawn significant scientific interest due to Thymosin Beta-4’s known role in actin regulation, which is fundamental to cell structure and movement.
TB-500 in Preclinical Research
Preclinical literature on TB-500 and its parent molecule Thymosin Beta-4 covers a range of biological phenomena:
- Cell migration: Thymosin Beta-4 is one of the most abundant intracellular peptides and plays a central role in G-actin sequestration, directly influencing how cells migrate in healing models.
- Angiogenesis research: Studies have explored TB4’s role in promoting new blood vessel formation, which is relevant to cardiac and wound biology research.
- Cardiac models: Several peer-reviewed studies examined Thymosin Beta-4 in myocardial infarction animal models, with observations on progenitor cell activation.
- Inflammation modulation: Laboratory research has examined the compound’s relationship to NF-κB signaling pathways involved in inflammatory cascades.
- Hair follicle biology: Some research has examined Thymosin Beta-4’s expression in hair follicle stem cell activation models.
Comparison with BPC-157 in Research Contexts
TB-500 and BPC-157 are frequently co-studied in laboratory settings because their proposed mechanisms are complementary. BPC-157 research has focused on localized tissue signaling and GI biology, while TB-500 research has emphasized systemic cell migration and angiogenic pathways. Researchers investigating recovery biology often study both compounds in parallel to examine potential synergistic effects in preclinical models.
Laboratory Handling & Storage
TB-500 is supplied as a lyophilized powder requiring reconstitution with bacteriostatic water. Lyophilized peptide is stable at -20°C for extended periods. Once reconstituted, store at 2–8°C and use within 28 days. As with all research peptides, maintain sterile handling conditions and document all laboratory procedures appropriately.
Purity & COA Documentation
Iron Labs TB-500 is third-party tested with HPLC purity confirmation and mass spectrometry identity verification. COAs are available on each product page for institutional documentation needs.
Regulatory Notice
TB-500 is not FDA-approved for any human or veterinary therapeutic application. It is classified as a research chemical and is sold by Iron Labs exclusively for use in qualified laboratory environments. No health claims are made or implied. This product is not a drug, supplement, or food.
Source TB-500 for your research → View Iron Labs research catalog